Positive allosteric modulation by ultraviolet irradiation on GABA A , but not GABA C , receptors expressed in Xenopus oocytes
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چکیده
منابع مشابه
Allosteric modulation of retinal GABA receptors by ascorbic acid.
Ionotropic GABA receptors (GABA(A) and GABA(C)) belong to the Cys-loop receptor family of ligand-gated ion channels. GABA(C) receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells. Ascorbic acid, an endogenous redox agent, modulates the function of diverse proteins, and basal levels of ascorbic acid in the retina are very high. However, the effect ...
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Cys-loop receptors are neurotransmitter-activated ion channels involved in synaptic and extrasynaptic transmission in the brain and are also present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR) belong to this family, we explored by macroscopic and single-channel recordings whether the inhibitory neurotransmitter GABA has the ability to activate excitatory nAChRs. GABA differe...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2001
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2001.0471c.xd